Recalcitrant pemphigus foliaceous and immunosuppressive treatment complications
نویسندگان
چکیده
منابع مشابه
Successful treatment of recalcitrant pemphigus vulgaris and pemphigus vegetans with etanercept and carbon dioxide laser.
A 26-year-old woman presented with a 5-month history of painful oral erosions and a 1-month history of widespread flaccid vesicles over her face and torso. A biopsy specimen of a skin lesion revealed suprabasal acantholysis. The diagnosis of pemphigus vulgaris (PV) was confirmed by a positive intercellular (IC) antibody titer. The patient was treated with prednisolone (30-45 mg/d) combined with...
متن کاملRituximab therapy improves recalcitrant Pemphigus vulgaris
Pemphigus is a severe life-threatening blistering disease associated with autoantibodies against cell adhesion proteins desmogleins 1 and 3. Patients with severe pemphigus commonly show high rates of relapse after conventional immunosuppressive therapy. The newly developed drug Rituximab showed impressing promises in the treatment of refractory pemphigus vulgaris (PV). In the present study the ...
متن کاملCharacterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens.
The adhesive proteins in the desmosome type of cell junction consist of two members of the cadherin superfamily, the desmogleins and desmocollins. Both desmogleins and desmocollins occur as at least three different isoforms with various patterns of expression. The molecular mechanisms controlling the differential expression of the desmosomal cadherin isoforms are not yet known. We have begun an...
متن کاملRecalcitrant pemphigus vulgaris: aseptic meningitis associated with intravenous immunoglobulin therapy and successful treatment with rituximab.
successful treatment with rituximab Dear Sir, We report the case of a 26-year-old woman with a 5-year history of a severe and recalcitrant pemphigus vulgaris (PV) (Fig. 1). During this period, the patient was treated with prednisolone, first combined with azathioprine and later with mycophenolate mofetil, but without complete response and always worsening when prednisolone tapering was attempte...
متن کاملRituximab in pemphigus foliaceous with autoantibodies against both Desmoglein 1 and Desmoglein 3.
415 5. Varga EA, Kerlin BA, Wurster MW. Social and ethical controversies in thrombophilia testing and update on genetic risk factors for venous thromboembolism. The effect of aspirin on haemostatic activity in the treatment of chronic venous leg ulceration. Pemphigus foliaceous (PF) is generally a benign autoim-mune blistering disease, but in some patients lesions are severe with serious implic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Research and Clinical Practice
سال: 2018
ISSN: 2397-9631
DOI: 10.15761/brcp.1000176